Preeclampsia Studies

Pre-Term Labor Studies

Inflammation Studies

Contraceptive Studies

Urogynecology

Oncology Studies

General Obstetrics

Community Grant

General Gynecology

Donna Johnson, MD

Alterations in the Plasma Proteome of Early-Onset Severe Preeclampsia

CTSA K-12 Scholar

The objectives of this study are to

• Compare the maternal plasma proteomes of early-onset, severe preeclampsia versus healthy controls.
  
• Compare protein expression and quantification of the maternal plasma proteome at the time of diagnosis of EOS-preeclampsia to the plasma proteome of the same affected subject at 48 hours post delivery.
  
• Verify the placental expression of differentially expressed of post-translationally modified proteins found in the plasma of women with EOS-preeclampsia.

Christopher Robinson, MD

Eugene Chang, MD

Early Placental Markers of Preeclampsia

The purpose of this study is to examine substances in the placenta that may increase the risk of preeclampsia. The study will compare the early placental tissue from women who have had normal, full term pregnancies to the placentas of women who have had a pregnancy (pregnancies) complicated by high blood pressure/or preeclampsia.

Mark Alanis, MD

Racial Disparities in Cervical Insufficiency and Cerclage Failure

The objective of this study is to compare the timing and the frequency of Premature Rupture of Membranes (PPROM) and PTB following cerclage placement among African-Americans and Caucasians.

Elizabeth Platz, MD

Progesterone Outreach Project

The primary objective of the Progesterone Outreach Project (POP) is to increase the appropriate administration of 17-p hydroxyprogesterone appropriate (17P) to women in the Lowcountry Perinatal Region (Charleston, Berkeley, Dorchester, Colleton, Georgetown, Beaufort, Jasper, and Hampton counties) with a history of spontaneous preterm birth by aggressive and consistent educational outreach to all Regional obstetrical providers.

Charles Rittenberg, MD

Differential Placental and Decidual Gene Expression to Elucidate the First Trimester Pathophysiologic Mechanisms Leading to Spontaneous Preterm Birth

The purpose of the study is to examine substances in the placenta that may increase the risk of a disease of pregnancy called spontaneous preterm birth.

A Novel Approach to the Prevention of Cervical Insufficiency and Preterm Delivery

SCTR Pilot Project

The objective of this study is to build, model and test a novel bifilament polymer to be used for the prevention of cervical insufficiency and preterm birth.

Scott Sullivan, MD

Scott Sullivan, MD

Fetal Inflammation in Term Pregnancy

The objectives of this study are to

• Establish the first large-scale cohort to evaluate biomarkers for maternal and fetal inflammation in term pregnancy.
  
• Elucidate the relative antepartum and intrapartum contributions to fetal inflammation.

Laura Goetzl, MD

Inflammation and the Treatment of Bacterial Vaginosis Near Term

The objective of this study is to determine the effect of standard therapy for bacterial vaginosis carriage on maternal serum markers of inflammation.

Heather Norton, MD

Inflammation in Early Pregnancy

The purpose of this study is to examine the substances in the placenta that may increase the risk of early delivery (preterm birth).

Margaret Villers, MD

Steven Swift, MD

Screening of Bone Mineral Density in Women Who Have Received Chemotherapy

The objective of this study is to obtain baseline bone mineral density (BMD) data on women with breast and gynecological cancers who have received chemotherapy.  By comparing the Z score of postmenopausal women who have received chemotherapy with age matched controls it can be determined whether women who have received chemotherapy have a greater bone loss than the same age controls.

William Creasman, MD

Rebecca Wineland, MD

Predictors of Successful Induction in Nulliparous Patients at Term

The objective of this study is to identify new biomarkers for the prediction of successful labor induction and to quantify the sensitivity and specificity of these biomarkers.

Meghan Lynch, MD

Robbie Conatser, MD

The National Standard for Normal Fetal Growth

The scope of this investigation is to study the fetal growth pattern in low risk and obese women of various racial/ethnic backgrounds in a longitudinal fashion to examine factors that influence normal fetal growth and perinatal outcomes. The research effort will fill important gaps in our knowledge about fetal growth. It will help identify important risk factors for altered growth and establish links between fetal growth, maternal nutrition, maternal metabolism, and other established maternal risk factors.

Roger Newman, MD

Obesity-Related Alterations in Placental Development and Function

The purpose of the study is to see if there is a relationship between body weight and the function of the placenta. The study will compare the early placental tissue between obese and non-obese women.

Mark Alanis, MD

Roger Newman, MD

Outreach Wellness House Transition Project

The objective of this study is to transition from a temporary to a permanent Wellness House. The project will accelerate the rate at which the new Wellness House can provide a full level of women's health and prenatal care, dental services and health education to low income residents of Johns Island, James Island and Wadmalaw Island, South Carolina.

Knowledge and Usage of Emergency Contraception by Women Seeking Abortions

The purpose of this study is to identify what percentage of women seeking abortions is aware that emergency contraception (EC) is available over the counter. A secondary goal is to identify barriers to use among women who were aware of EC and did not use it.

Gretchen Reinhart, MD

A Randomized, International, Double-Blinded (With In-House Blinding),Controlled With GARDASIL(TM), Dose-Ranging, Tolerability, Immunogenicity, and Efficacy Study of a Multivalent Human Papillomavirus (HPV) L1 Virus-Like Particle (VLP) Vaccine Administered to 16- to 26-Year-Old Women

The purpose of this study is to test the safety and effectiveness of the 9-valent HPV as compared to GARDASIL®.

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David Soper, MD