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Home > Women's Health > Research > Department Research, Grants, & Clinical Trials
Department Research, Grants, & Clinical Trials

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CURRENT RESEARCH STUDIES

Preeclampsia Studies

Pre-Term Labor Studies

Inflammation Studies

Contraceptive Studies

Urogynecology

Oncology Studies

General Obstetrics

General Gynecology

Community Grant

Animal Studies

Preeclampsia Studies

Assay R & D Preeclampsia Sample Collection Protocol

The objective of this study is to collect samples and data to support the development of an in vitro diagnostic device, IVDD, that can be used as an aid in diagnosis of preeclampsia.

Dr. Johnson
Donna Johnson, MD


Soluble FMS-Like Tyrosine Kinase 1 (SFLT-1), Placental Growth Factor (PLGF) Levels as Predictors of Preeclampsia Prior to Onset of Symptoms in Pregnant Women, as an Aid in Diagnosis in Symptomatic Women and for Risk Stratification

The objectives of this study are to:

  • Collect data to support an in vitro diagnostic device, IVDD, that can accurately predict preeclampsia prior to onset of symptoms in pregnant women and aid in the diagnosis of preeclampsia.
  • Assess the biomarkers' ability to stratify patients at risk of preeclampsia.
  • Expand OCD's sample bank for future use in the development and validation of research methods, biomarkers, diagnostic tools, therapeutic targets, and clinical assays for obstetric diseases.

Alterations in the Plasma Proteome of Early-Onset Severe Preeclampsia

CTSA K-12 Scholar


The objectives of this study are to:

  • Compare the maternal plasma proteomes of early-onset, severe preeclampsia versus healthy controls.
  • Compare protein expression and quantification of the maternal plasma proteome at the time of diagnosis of EOS-preeclampsia to the plasma proteome of the same affected subject at 48 hours post delivery.
  • Verify the placental expression of differentially expressed of post-translationally modified proteins found in the plasma of women with EOS-preeclampsia.

Dr. Robinson
Christopher Robinson, MD

Endothelial Progenitor Cells in Umbilical Cord Blood in Preeclamspsia and IUGR

The objective of this study is to determine whether there are alterations in the population of endothelial progenitor cells in umbilical cord blood samples of infants born in the setting of maternal preeclampsia or fetal growth restriction.

Dr. Ryan
Ashley Ryan, MD

Early Placental Markers of Preeclampsia

The purpose of this study is to examine substances in the placenta that may increase the risk of preeclampsia. The study will compare the early placental tissue from women who have had normal, full term pregnancies to the women to the placentas of women who have had a pregnancy (pregnancies) complicated by high blood pressure/or preeclampsia.

Mark Alanis, MD

Pre-Term Labor Studies

Racial Disparities in Cervical Insufficiency and Cerclage Failure

The objective of this study is to compare the timing and the frequency of Premature Rupture of Membranes (PPROM) and PTB following cerclage placement among African-Americans and Caucasians.

Dr. Platz
Elizabeth Platz, MD

Progesterone Outreach Project

The primary objective of the Progesterone Outreach Project (POP) is to increase the appropriate administration of 17-p hydroxyprogesterone appropriate (17P) to women in the Lowcountry Perinatal Region (Charleston, Berkeley, Dorchester, Colleton, Georgetown, Beaufort, Jasper, and Hampton counties) with a history of spontaneous preterm birth by aggressive and consistent educational outreach to all Regional obstetrical providers.

Dr. Rittenberg
Charles Rittenberg, MD

A Novel Approach to the Prevention of Cervical Insufficiency and Preterm Delivery

SCTR Pilot Project

The objective of this study is to build, model and test a novel bifilament polymer to be used for the prevention of cervical insufficiency and preterm birth.

Dr. Sullivan

Scott Sullivan, MD

Inflammation Studies

Fetal Inflammation in Term Pregnancy

The objectives of this study are to:

  • Establish the first large-scale cohort to evaluate biomarkers for maternal and fetal inflammation in term pregnancy
  • Elucidate the relative antepartum and intrapartum contributions to fetal inflammation

Dr. Goetzl
Laura Goetzl, MD

Inflammation and the Treatment of Bacterial Vaginosis Near Term

The objective of this study is to determine the effect of standard therapy for bacterial vaginosis carriage on maternal serum markers of inflammation

Dr. Norton
Heather Norton, MD

Urogynecology

The Test Retest Reliability of the Q-Tip Test

The objective of this study is to investigate the test-retest reliability of the Q-tip test over time and possibly reinforce its importance in the evaluation of women who present with complaints of urinary incontinence.

Dr. Swift
Steven Swift, MD

A Multicenter, Randomized, Double-Blind, Parallel Group Study to Evaluate the Efficacy and Safety of Two Doses of DR-3001 versus Placebo in Women with Overactive Bladder

The purpose of this research is to study the safety and effectiveness of an experimental vaginal ring that administers a medication called oxybutynin for treating overactive bladder.

Oncology Studies

Screening of Bone Mineral Density in Women Who Have Received Chemotherapy

The objective of this study is to obtain baseline bone mineral density (BMD) data on women with breast and gynecological cancers who have received chemotherapy.  By comparing the Z score of postmenopausal women who have received chemotherapy with age matched controls it can be determined whether women who have received chemotherapy have a greater bone loss than the same age controls.


Dr. Creasman
William Creasman, MD

Role of HPV Genotype in Depth of Stromal Invasion in Invasive Cervical Cancer

The objective of this study is to determine HPV genotype distribution by race in surgical specimens from all cases of state IA-IIA cervical cancer treated with radical hysterectomy at our institution.

Dr. Rebecca Wineland
Rebecca Wineland, MD

General Obstetrics

The Pregnancy Environment and Child Health (PEACH)

The objective of this study is to assess the association between concentration of maternal halogenated organic compounds (HOC) and child health.  Specifically, the primary objective of the study is to assess whether exposure to HOC (such as PCB, DDE, PBDE and HOPCB) in utero or via breastfeeding poses a risk for the immune system of the child, taking the protective effect of breastfeeding into consideration.

Dr. Goetzl
Laura Goetzl, MD
and Wilfried Karmaus (USC)

Predictors of Successful Induction in Nulliparous Patients at Term

The objective of this study is to identify new biomarkers for the prediction of successful labor induction and to quantify the sensitivity and specificity of these biomarkers.

Dr. Lynch
Meghan Lynch, MD

A Randomized, Prospective Trial Comparing the use of the Alexis Retractor System during Cesarean Section with Traditional Retractors

The purpose of this study is to compare the effectiveness of the Alexis retractor system for the prevention of infection and excessive blood loss to patients undergoing a cesarean delivery.

Dr. Conaster
Robbie Conatser, MD

The National Standard for Normal Fetal Growth

The scope of this investigation is to study the fetal growth pattern in low risk and obese women of various racial/ethnic backgrounds in a longitudinal fashion to examine factors that influence normal fetal growth and perinatal outcomes. The research effort will fill important gaps in our knowledge about fetal growth. It will help identify important risk factors for altered growth and establish links between fetal growth, maternal nutrition, maternal metabolism, and other established maternal risk factors.

Dr. Roger Newman
Roger Newman, MD

Community Grant

Obesity Prevention Teams in our Neighborhood Schools (OPTIONS)

The objective of this study is to prevent obesity, improve healthy nutrition education and behaviors, and enhance physical fitness activity among students from a socioeconomically disadvantaged, African-American population attending Title 1 Charleston peninsula elementary schools.

Dr. Roger Newman
Roger Newman, MD

Outreach Wellness House Transition Project

The objective of this study is to transition from a temporary to a permanent Wellness House. The project will accelerate the rate at which the new Wellness House can provide a full level of women's health and prenatal care, dental services and health education to low income residents of Johns Island, James Island and Wadmalaw Island, South Carolina.

Animal Studies

Circadian Factor Involvement in Prolactin Gene Expression

The objective of this study is to elucidate the mechanisms of PRL-GE pulsality especially with respect to circadian transcription factors.

Dr. Eddie Tarnawa
Eddie Tarnawa, MD

Contraceptive Studies

Knowledge and Usage of Emergency Contraception by Women Seeking Abortions

The purpose of this study is to identify what percentage of women seeking abortions is aware that emergency contraception (EC) is available over the counter. A secondary goal is to identify barriers to use among women who were aware of EC and did not use it.

Gretchen Reinhart, MD

Page last updated: 11/07/08
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