MUSC Pancreas Transplant Program

musc transplant center

Transplant Selection Criteria

Individuals who have insulin dependent diabetes accompanied by advanced, chronic renal failure, or who are on dialysis may be good candidates for a simultaneous pancreas and kidney transplant (SPK). SPK is a transplant procedure where both a kidney and a pancreas are transplanted at the same time using organs from a deceased donor. The procedure frees patients from dialysis and insulin dependency.

Patients who are eligible for SPK typically have:

Individuals who have insulin dependent diabetes and a documented progression of secondary complications, despite intensive medical intervention may be eligible for either a pancreas transplant alone (PTA) or a pancreas transplant after a kidney transplant (PAK). Among their symptoms are:

  • Progression of secondary diabetic complications, such as:
    • Diabetic retinopathy
    • Diabetic peripheral or automatic neuropathy
    • Diabetic gastroperesis
    • Progressive atherosclerosis
  • Neuroglycopenia with unawareness
  • Recurrent diabetic ketoacidosis
  • Actual 24-hour urine collection that has creatinine clearance greater than or equal to 40 cc/minute and proteinuria of less than one gram (PAK)
  • Actual 24-hour urine collection that has creatinine clearance greater than or equal to 60 cc/minute and proteinuria of less than 1 gram (PTA)

Patients are not good candidates for pancreas transplantation if they have:

  • Malignancy within the past two years (other than skin)
  • Cardiovascular or pulmonary disease sufficiently severe to prevent surgery
  • A positive test for human immunodeficiency virus (HIV)
  • Active infection
  • A body mass index of more than 30
  • Active alcohol or substance abuse (must be abstinent for six months and have successfully completed a treatment program)

No smoking is strongly advocated for all potential pancreas transplant patients.

 
 
 

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