Neurosciences News and Events

Mickey, a 3 year-old who had case of Bobble-Head Doll Syndrome, a rare condition that resulted in him bobbing his head in a “yes-yes” motion was treated at MUSC this summer.  WCBD Channel 2 joined Mickey, his Mom and Dr. Sunil Patel for this follow-up visit in the news story below.

WCBD-TV: News, Weather, and Sports for Charleston, SC

To learn more about Bobble-Head Doll Syndrome and Mickey’s case, read the story in the August, 2013 Progress Notes and watch an interview with Dr. Patel.

A free educational Brain Tumor support group designed to help adults with brain tumors improve their quality of life, and share their experiences. Brain Tumor Support Group

Please join us to learn about resources and treatment options, share information and develop new relationships. Patients and their families are welcome. Lunch will be provided. For more information call 843-792-8552.

Date: 1st Thursday of every month
Time: 12 to 1 p.m.
Location: MUSC Clinical Sciences Building, Room 429, 96 Jonathan Lucas Street, Charleston, SC

Please RSVP to Brittaine Hinkson at 843-792-855

Find out more about the MUSC Brain and Spine Tumor program.

The work of MUSC's Neuro-Oncology research and clinical teams was featured on the cover of the August Journal of Neuro-Oncology for their work in discovering the first direct evidence that the compound DATS, found in garlic, is effective in blocking pathways of the proliferation of cancer cells and ultimately may help reduce tumor growth in patients with glioblastoma, the most lethal brain tumor.

To learn more about this exciting research, please visit the MUSC Newsroom for a full article.

Dr. Sunil Patel, Chief of Neurosurgery at the Medical University of South Carolina, discusses a rare case of Bobble-Head Doll Syndrome. Characterized by a "yes-yes" head bob, the syndrome is often associated with cystic abnormalities in the third ventricle that produce hydrocephalus. Opting against the traditional craniotomy, Dr. Patel drained the cyst endoscopically—a 15-minute procedure requiring an incision only an inch long. MUSC specializes in minimally invasive endoscopic neurosurgery.

Press Release: MUSC study: Alzheimer’s disease linked to high fat diets

Evidence mounts that what’s bad for the body is bad for the mind

Recent evidence suggests that metabolic disorders and many diseases frequently develop due to unhealthy lifestyles, such as poor diet and lack of physical activity. Researchers Narayan R. Bhat, Ph.D., Medical University of South Carolina (MUSC) neurosciences professor and Lakshmi Thirumangalakudi, Ph.D., Department of Psychiatry, College of Physicians and Surgeons, Columbia University Medical Center and New York State Psychiatric Institute, have found evidence to suggest that what’s bad for the body is also bad for the mind in a study published this month in the Journal of Alzheimer's Disease.

            “Alzheimer’s disease (AD) progressively robs its victims of their memory, mental faculties and independent living,” Bhat said. “Although specific genetic mutations have been identified that

directly cause the disease, these cases are rare. Our study suggests potential common causes and co-morbidities of metabolic disorders and sporadic cases of Alzheimer’s disease and hence an opportunity to develop treatments targeted at improving insulin sensitivity for those more common cases of AD.”

Epidemiological and experimental studies point to a link between metabolic diseases and Alzheimer’s-like dementia via common vascular-associated risk factors. Although the underlying mechanisms are unclear and complex, certain common features are emerging including inflammation and insulin resistance, leading to changes in metabolic derangement in the brain similar to peripheral organs. In fact, some researchers now describe AD as “type 3 diabetes” –a consequence of insulin deficiency and inaction (i.e., resistance). One of the consequences of altered insulin signaling and resistance in the brain is increased phosphorylation of tau, a brain protein that loses its normal function while becoming toxic in the AD brain.

In their study Bhat and Thirumangalakudi describe brain changes that indicate altered insulin signaling and increased tau phosphorylation in normal mice fed a high-fat and high-cholesterol diet. The hypothesis for the link between vascular disorders and AD-like changes in the brain is that metabolic changes including peripheral inflammation and insulin resistance resulting from high fat intake cause dysfunction in the brain’s vascular system that in turn leads to cellular and metabolic changes in the brain similar to what occurs in an AD brain. For more information, a full citation of the study is here:

Increased Tau Phosphorylation and Impaired Brain Insulin/IGF Signaling in Mice Fed a High Fat/High Cholesterol Diet

Narayan R. Bhat and Lakshmi Thirumangalakudi

JAD Volume 36/Issue 4 (August 2013)

DOI: 10.3233/JAD-2012-121030


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