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Health Library : Dermatology


Fifth Disease

What is fifth disease?

Fifth disease is a viral illness that is associated with an exanthem. Exanthem is another name for a rash or skin eruption that occurs due to an infection or disease. Fifth disease is also known as erythema Infectiosum and as "slapped cheek" disease because the rash can cause a child's cheeks to become quite red. Fifth disease is spread from one child to another through direct contact with discharge from the nose and throat. It can also be spread through contact with infected blood. It is moderately contagious.

What causes fifth disease?

Fifth disease is caused by the human parvovirus B19. It is most prevalent in the winter and spring and is usually seen in school age children. Outbreaks of the disease frequently occur in school settings. Adults can get fifth disease too, but most of these infections are in children.

What are the symptoms of fifth disease?

It may take between four to 14 days for the child to develop symptoms of fifth disease after being exposed to the disease. About 80 percent of children have very mild symptoms for about a week before developing the rash. About 20 percent will have no symptoms at all before the rash appears. Children are most contagious before the rash occurs. Therefore, children are contagious before they even know they have the disease. The following are the most common symptoms of fifth disease. However, each child may experience symptoms differently. Symptoms may include:

  • There may be an early phase with the following symptoms, although the symptoms are sometimes very mild and nearly unnoticed. If present, symptoms may include the following:
    • Fever, usually low-grade
    • Headache
    • Runny nose
    • Sore throat
    • Itching
    • Nausea, vomiting, or diarrhea
  • The rash is usually the primary symptom of fifth disease. The rash:
    • Starts on the cheeks and is bright red; The rash looks like "slapped" cheeks.
    • Then spreads to the trunk, arms, and legs, and lasts two to four days; It often has a "lacey" appearance.
    • May then continue to reappear if the child is exposed to sunlight, very hot or cold temperature, or trauma to the skin; This may continue for several days.

Pregnant women who have been exposed to fifth disease need to seek medical attention.

Fifth disease is usually a mild illness. However, parvovirus B19 infection may cause an acute severe anemia in persons with sickle-cell disease or immune deficiencies. There is a small risk of fetal death if fifth disease is acquired during pregnancy.

The symptoms of fifth disease may resemble other conditions or medical problems. Always consult your child's doctor for a diagnosis.

How is fifth disease diagnosed?

Fifth disease is usually diagnosed based on a complete medical history and physical examination of your child. The rash and progression of fifth disease is unique, and usually allows for a diagnosis simply on physical examination. In addition, your child's doctor may order blood tests to aid in the diagnosis.

Aspirin and the risk of Reye syndrome in children

Do not give aspirin to a child without first contacting the child's doctor. Aspirin, when given as treatment for children, has been associated with Reye syndrome, a potentially serious or deadly disorder in children. Therefore, pediatricians and other health care providers recommend that aspirin (or any medication that contains aspirin) not be used to treat any viral illnesses in children.

Treatment for fifth disease

The goal of treatment for fifth disease is to help decrease the severity of the symptoms. Since it is a viral infection, there is no cure for fifth disease. Treatment may include:

  • Increased fluid intake
  • Acetaminophen or ibuprofen for fever (DO NOT GIVE ASPIRIN to children as aspirin may cause a serious health condition called Reye syndrome)
  • An antihistamine for itching

Measures to prevent transmission of fifth disease and other illnesses include frequent hand-washing with soapy water, and covering the mouth and nose when coughing or sneezing.

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Online Resources of Dermatology

 Sources & References


 Treatment at MUSC:
 »Dermatology Clinic



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