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Health Library : Endocrinology

 

Pancreatic Cancer

What is pancreatic cancer?

Pancreatic cancer is the fourth most common cause of cancer death in men and women in the US. According to the American Cancer Society,45,000 new cases of pancreatic cancer and about 38,000 deaths were expected in 2013. Pancreatic cancer occurs when a cell in the pancreas is damaged and this malignant (cancer) cell starts to grow out of control.

What is a risk factor?

A risk factor is anything that may increase a person's chance of developing a disease. It may be an activity, such as smoking, diet, family history, or many other things. Different diseases, including cancers, have different risk factors.

Although these factors can increase a person's risk, they do not necessarily cause the disease. Some people with one or more risk factors never develop the disease, while others develop disease and have no known risk factors.

But, knowing your risk factors to any disease can help to guide you into the appropriate actions, including changing behaviors and being clinically monitored for the disease.

Risk factors for pancreatic cancer include:

  • age - most pancreatic cancer occurs in people over the age of 55.
  • smoking - heavy cigarette smokers are two or three times more likely than non-smokers to develop pancreatic cancer.
  • obesity and physical inactivity - pancreatic cancer is more common in people who are overweight and in people who don't get much physical activity.
  • diabetes - pancreatic cancer occurs more often in people who have type 2 diabetes than in those who do not.
  • gender - more men than women are diagnosed with pancreatic cancer.
  • race - African Americans are more likely than Asians, Hispanics, or Caucasians to be diagnosed with pancreatic cancer.
  • family history - the risk for developing pancreatic cancer is high if a person's mother, father, or a sibling had the disease.
  • cirrhosis of the liver - people with cirrhosis have a higher risk of pancreatic cancer.
  • workplace exposure - exposure to certain occupational pesticides, dyes and chemicals used in the metal industry may increase the risk of pancreatic cancer.
  • some genetic syndromes - certain inherited gene mutations, such as in the BRCA2 gene, increase the risk of pancreatic cancer.
  • chronic pancreatitis - this condition of the pancreas has been linked with increased risk for pancreatic cancer.

There are several types of pancreatic cancers, including the following:

  • adenocarcinoma of the pancreas - the most common pancreatic cancer, which occurs in the lining of the pancreatic duct.
  • cystadenocarcinoma - a rare pancreatic cancer.
  • acinar cell carcinoma - a rare pancreatic cancer.

Some neuroendocrine tumors in the pancreas include the following - they may be benign (noncancerous) or malignant (cancerous):

  • insulinoma - a rare pancreatic tumor that secretes insulin, the hormone that lowers glucose levels in the blood.
  • gastrinoma - a tumor that secretes above average levels of gastrin, a hormone that stimulates the stomach to secrete acids and enzymes. Gastrinoma can cause peptic ulcers.
  • glucagonoma - a tumor that secretes glucagon, a hormone that raises levels of glucose in the blood, often leading to a rash.

What are the symptoms of pancreatic cancer?

The following are the other most common symptoms of pancreatic cancer. However, each individual may experience symptoms differently. Symptoms may include:

  • pain in the upper abdomen (belly) or upper back
  • loss of appetite
  • weight loss
  • jaundice (yellow skin and eyes, and dark urine)
  • indigestion
  • nausea
  • vomiting
  • extreme tiredness (fatigue)
  • an enlarged abdomen from a swollen gallbladder
  • pale, greasy stools that float in the toilet

The symptoms of pancreatic cancer may be a lot like those of other conditions or medical problems. Always consult your physician for a diagnosis.

Picture of a patient in a scanner

How is pancreatic cancer diagnosed?

In addition to a complete medical history and physical examination, diagnostic procedures for pancreatic cancer may include the following:

  • ultrasound (Also called sonography.) - a diagnostic imaging technique that uses high-frequency sound waves to create an image of the internal organs. Ultrasounds are used to view internal organs of the abdomen such as the liver, pancreas, spleen, and kidneys and to assess blood flow through various vessels. The ultrasound may be done using an external or internal device:
    • transabdominal ultrasound - the technician places an ultrasound device on the abdomen to create the image of the pancreas.
    • endoscopic ultrasound (EUS) - the physician inserts an endoscope, a small, flexible tube with an ultrasound device at the tip, through the mouth and stomach, and into the small intestine. As the physician slowly withdraws the endoscope, images of the pancreas and other organs are made.
  • computed tomography scan (CT or CAT scan) - a diagnostic imaging procedure that uses a combination of x-rays and computer technology to produce cross-sectional images (often called slices), both horizontally and vertically, of the body. A CT scan shows detailed images of any part of the body, including the bones, muscles, fat, and organs. CT scans are more detailed than general x-rays.
  • magnetic resonance imaging (MRI) - a diagnostic procedure that uses a combination of large magnets, radiofrequencies, and a computer to produce detailed images of organs and structures within the body.
  • magnetic resonance cholangiopancreatography (MRCP) - a special type of MRI that uses radio waves and magnets to obtain pictures of the bile ducts and internal organs.
  • endoscopic retrograde cholangiopancreatography (ERCP) - a procedure that allows the physician to diagnose and treat problems in the liver, gallbladder, bile ducts, and pancreas. The procedure combines x-ray and the use of an endoscope - a long, flexible, lighted tube. The scope is guided through the patient's mouth and throat, then through the esophagus, stomach, and duodenum (first part of the small intestine). The physician can examine the inside of these organs and detect any abnormalities. A tube is then passed through the scope, and a dye is injected which will allow the bile and pancreatic ducts to be seen on an x-ray.
  • percutaneous transhepatic cholangiography (PTC) - a needle is put through the skin and into the liver where the dye (contrast) is injected so that the bile duct structures can be seen by x-ray. This test is generally only done if an ERCP cannot be done.
  • pancreas biopsy - a procedure in which a sample of pancreatic tissue is removed (with a needle or during surgery) for examination under a microscope.
  • special blood tests
  • positron emission tomography (PET) - a type of nuclear medicine procedure. For this test, a radioactive substance, usually bound to a type of sugar, is injected through a vein before the body is scanned. The radioactive sugar collects in cancer cells, which will show up on images. This test is not as specific as CT scanning, and is not sued alone to diagnose pancreatic cancer. A PET scan is often done in combination with a CT scan.

Treatment for pancreatic cancer:

Specific treatment for pancreatic cancer will be determined by your physician based on:

  • your age, overall health, and medical history
  • location and extent of the disease
  • type of cancer
  • your tolerance of specific medicines, procedures, or therapies
  • expectations for the course of the disease
  • your opinion or preference

Depending upon the type and stage, pancreatic cancer may be treated with the following:

  • surgery - may be necessary to remove the tumor - a section or the entire pancreas and often parts of other organs. The type of surgery depends on the stage of the cancer, the location and size of the tumor, and the person’s health. Types of surgery for pancreatic cancer include the following:
    • Whipple procedure - this procedure involves removal of the head of the pancreas, part of the small intestine, the gall bladder and part of the common bile duct, part of the stomach, and lymph nodes near the head of the pancreas. Most pancreatic tumors occur in the head of the pancreas, so the Whipple procedure is the most commonly performed surgical procedure for pancreatic cancer.
    • distal pancreatectomy - if the tumor is located in the body and tail of the pancreas, both of these sections of the pancreas will be removed, along with the spleen.
    • total pancreatectomy - the entire pancreas, part of the small intestine and stomach, the common bile duct, the spleen, the gallbladder, and some lymph nodes will be removed. This type of operation is not done often.
    • palliative surgery - for more advanced cancers, surgery may not be done to try to cure the cancer, but to relieve problems such as a blocked bile duct.
  • external beam radiotherapy (EBRT) - EBRT uses carefully aimed beams of x-rays to kill cancer cells. EBRT is painless and takes a few minutes to deliver. The treatment plan is developed by a doctor called a Radiation Oncologist. Special techniques such as Intensity-Modulated Radiotherapy (IMRT) and Tomotherapy are often used to minimize the dose of radiation to normal tissues to reduce side effects, while still delivering enough radiation to kill tumor cells and shrink tumors. EBRT is often used before or after surgery, in combination with chemotherapy, to reduce the likelihood of tumor recurrence. EBRT is also used to ease symptoms (palliate) such as pain, blockage, or bleeding.
  • chemotherapy - the use of anticancer drugs to kill cancer cells. In most cases, chemotherapy works by interfering with the cancer cell’s ability to grow or reproduce. Different groups of drugs work in different ways to fight cancer cells. The oncologist will recommend a treatment plan for each individual. Chemotherapy may be given alone, or in combination with surgery and radiation therapy.
  • medication (to relieve or reduce pain)

Long-term prognosis for individuals with pancreatic cancer depends on the size and type of the tumor, lymph node involvement, and degree of metastases (spreading) at the time of diagnosis.

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