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Cancer Health Library : Gyn Oncology

Cancer Types - Cervical Cancer

What is the cervix?

The cervix is the lower, narrow part of the uterus (womb) located between the bladder and the rectum. It forms a canal that opens into the vagina, which leads to the outside of the body.

What are precancerous conditions of the cervix?

Precancerous conditions of the cervix are identified as the presence of cells that look abnormal, but are not cancerous at the present time. However, the appearance of these abnormal cells may be the first evidence of cancer that develops years later.

Precancerous changes of the cervix usually do not cause pain and, in general, do not cause any symptoms. They are detected with a Pap test.

Squamous intraepithelial lesions (SIL) is a term that refers to abnormal changes in the cells on the surface of the cervix.

  • squamous cells are the flat cells found on the surface (of the cervix)
  • intraepithelial means that the abnormal cells are present only in the surface layer of cells
  • lesion refers to an area of abnormal tissue

According to the National Cancer Institute (NCI), changes in these cells can be divided into two categories:

Chlamydia and Cervical Cancer

New research has shown that chlamydia, the most common sexually transmitted disease in the US, may increase a woman's risk of developing cervical cancer. In the study, published in the Journal of the American Medical Association (JAMA), women who showed signs of any type of chlamydial infection in their blood were two-and-a-half times more likely to develop cervical cancer, when compared to women with no sign of infection. Although the reason for this increased risk is still under investigation, researchers speculate that immune system cells that are activated at chlamydia infection sites may damage normal cells.

  • Low-grade SIL refers to early changes in the size, shape, and number of cells that form the surface of the cervix. They may go away on their own, or, with time, may grow larger or become more abnormal, forming a high-grade lesion.

    These changes may also be called mild dysplasia or cervical intraepithelial neoplasia 1 (CIN 1).
  • High-grade SIL means there are a large number of precancerous cells, and, like low-grade SIL, these changes involve only cells on the surface of the cervix. The cells often do not become cancerous for many months, perhaps years, but without treatment they will become cancer.

    High-grade lesions may also be called moderate or severe dysplasia, CIN 2 or 3, or carcinoma in situ.

What is cancer of the cervix?

If abnormal cells on the surface of the cervix spread deeper into the cervix, or to other tissues or organs, the disease is then called cervical cancer, or invasive cervical cancer. Cervical cancer occurs most often in women younger than the age of 50. It is different from cancer that begins in other parts of the uterus and requires different treatment. Most cervical cancers are squamous cell carcinomas and adenocarcinomas.

The mortality rates for cervical cancer have declined sharply as Pap screenings have become more prevalent. According to the American Cancer Society (ACS) about 12,170 cases of invasive cervical cancer will be diagnosed in the US during 2012. Some researchers estimate that noninvasive cervical cancer (also referred to as "carcinoma in situ") is nearly four times more common than invasive cervical cancer.

What is a risk factor?

A risk factor is anything that may increase a person's chance of developing a disease. It may be an activity, such as smoking, diet, family history, or many other things. Different diseases, including cancers, have different risk factors.

Although these factors can increase a person's risk, they do not necessarily cause the disease. Some people with one or more risk factors never develop cancer, while others develop cancer and have no known risk factors.

But, knowing your risk factors to any disease can help to guide you into the appropriate actions, including changing behaviors and being clinically monitored for the disease.

What are risk factors for cervical cancer?

The following have been suggested as risk factors for cervical cancer:

  • infection with the human papillomavirus (HPV)
    HPV is the cause of nearly all cervical cancers. Infection with HPV is most often the result of unprotected sex.
  • not getting regular Pap tests
    Cervical cancer is more common in women who don't have regular Pap tests. Pap tests help doctors find abnormal cells. These cells can be removed, which usually prevents cervical cancer.
  • infection with the human immunodeficiency virus (HIV) or other conditions that weaken the immune system
    HIV is the precursor to AIDS. Taking drugs that suppress the immune system also increases the risk of cervical cancer.
  • smoking
    Women who smoke are nearly twice as likely as nonsmokers to have cervical cancer.
  • diet
    Women with diets low in fruits and vegetables and overweight women are at increased risk for cervical cancer.
  • chlamydia infection
    Some studies have seen a higher risk of cervical cancer in women whose blood test results show evidence of past or current chlamydia infection when compared with women who have normal test results. Chlamydia is spread by sexual contact.
  • using birth control pills for a long time
    Using birth control pills for 5 or more years may slightly increase the risk of cervical cancer, but the risk decreases when women stop using birth control pills.
  • having many children
    Studies suggest that giving birth to 3 or more children may slightly increase the risk of cervical cancer in women with HPV infection.
  • having many sexual partners, and having partners who have had many partners themselves
  • first full term pregnancy at young age
    Women who were younger than 17 years when they had their first full-term pregnancy are almost 2 times more likely to get cervical cancer later in life than women who waited until they were 25 years or later to get pregnant.
  • poverty
    many low income women do not have access to adequate health care services, including Pap tests. So they are not screened or treated for cervical pre-cancers.
  • family history of cervical cancer
    This cancer may run in some families. A woman's chances of developing it are 2 to 3 times higher if her mother or sister had cervical cancer than if no one in her family had it.
  • diethylstilbestrol (DES)
    DES is a drug that was used to prevent miscarriage between 1940 and 1971. Women whose mothers took DES while pregnant with them develop this cancer more than would normally be expected. The risk seems to be highest in women whose mothers took the drug during their first 16 weeks of pregnancy. (The FDA stopped the use of DES during pregnancy in 1971.)

Can cervical cancer be prevented?

Early detection of cervical problems is the best way to prevent cervical cancer. Routine, annual pelvic exams and Pap tests can detect precancerous conditions that often can be treated before cancer develops. Invasive cancer that does occur would likely be found at an earlier stage. Pelvic exams and Pap tests are used to determine if there are cervical problems. Women who are age 21 or older should have regular checkups, including a pelvic examination and Pap test.

According to the National Institutes of Health (NIH):

A pelvic examination and Pap test allow the physician to detect abnormal changes in the cervix. If an infection is present, it is treated and the Pap test is repeated at a later time. If the examination or Pap test suggests something other than an infection, a repeated Pap test and other tests are performed to determine the problem.

Women who have had a hysterectomy (surgery to remove the uterus, including the cervix) should ask their physician's advice about having pelvic examinations and Pap tests.

Because certain strains of HPV have been found to cause most cases of cervical cancer, research efforts have focused on developing a vaccine against HPV. Two HPV vaccines have been developed, and clinical trials of these vaccines have been successful.

  • Gardasil`#174; protects against four types of the HPV virus--the two types of viruses that cause most cervical cancers, and the two that cause 90 percent of genital warts. It protects against other cancers caused by HPV, too, such as cancers and pre-cancers of the vagina, vulva and anus.
  • Cervarix® protects against the two types of the HPV virus that cause most cervical cancers. It protects against anal cancers, too.

These vaccines can only be used to prevent certain types of HPV infection before a person is infected. They cannot be used to treat an existing HPV infection.

Both vaccines are administered as a series of three injections over a six month period. to be most effective, one of the vaccines should be given before a person becomes sexually active.

What are the symptoms of cervical cancer?

Symptoms of cervical cancer usually do not appear until abnormal cervical cells become cancerous and invade nearby tissue.

  • The most common symptom is abnormal bleeding, which may:
    • start and stop between regular menstrual periods.
    • occur after sexual intercourse, douching, or a pelvic exam.
  • Other symptoms may include:
    • heavier menstrual bleeding, which may last longer than usual
    • bleeding after menopause
    • increased vaginal discharge
    • pain during intercourse

The symptoms of cervical cancer may resemble other conditions or medical problems. Consult a physician for diagnosis.

How is cervical cancer diagnosed?

When cervical problems are found during a pelvic examination, or abnormal cells are found through a Pap test, a cervical biopsy may be performed. A biopsy is a procedure in which tissue samples are removed from the body for examination under a microscope to determine if cancer or other abnormal cells are present. The diagnosis of cancer is confirmed only by a biopsy.

There are several types of cervical biopsies that may be used to diagnose cervical cancer. Some of these procedures that completely remove areas of abnormal tissue may also be used for treatment of precancerous lesions. Some biopsy procedures only require local anesthesia, while others require a general anesthesia. Several types of cervical biopsies include:

  • loop electrosurgical excision procedure (LEEP) - a procedure that uses an electric wire loop to obtain a piece of tissue.
  • colposcopy - a procedure that uses an instrument with magnifying lenses, called a colposcope, to examine the cervix for abnormalities. If abnormal tissue is found, a biopsy is usually performed (colposcopic biopsy).
  • endocervical curettage (ECC) - a procedure that uses a narrow instrument called a curette to scrape the lining of the endocervical canal. This type of biopsy is usually completed along with the colposcopic biopsy.
  • cone biopsy (Also called conization.) - a biopsy in which a larger cone-shaped piece of tissue is removed from the cervix by using the loop electrosurgical excision procedure or the cold knife cone biopsy procedure. The cone biopsy procedure may be used as a treatment for precancerous lesions and early cancers.
  • HPV DNA test - a test that examines the DNA of cervical cells. The cells are collected as they are for a regular Pap test, but it is not a replacement for a Pap test. The HPV DNA test may be used as a screening test for women over 30 or for women with slightly abnormal Pap test results to determine if further testing or treatment is required.
  • cold knife cone biopsy - a procedure in which a laser or a surgical scalpel is used to remove a piece of tissue. This procedure requires the use of general anesthesia.

Treatment for cervical cancer:

Specific treatment for cervical cancer will be determined by your physician based on:

  • your overall health and medical history
  • extent of the disease
  • your tolerance for specific medications, procedures, or therapies
  • expectations for the course of the disease
  • your opinion or preference

Treatment may include:

  • surgery, including:
    • cryosurgery - use of liquid nitrogen, or a probe that is very cold, to freeze and kill cancer cells.
    • laser surgery - use of a powerful beam of light, which can be directed to specific parts of the body without making a large incision, to destroy abnormal cells.
    • hysterectomy - surgery to remove the uterus, including the cervix. In some cases, a hysterectomy may be required, particularly if abnormal cells are found inside the opening of the cervix.
  • radiation therapy - radiation therapy is the use of high-energy radiation to kill cancer cells and to shrink tumors. There are two ways to deliver radiation therapy, including the following:
    • external radiation (external beam therapy) - a treatment that precisely sends high levels of radiation directly to the cancer cells. The machine is controlled by the radiation therapist. Since radiation is used to kill cancer cells and to shrink tumors, special shields may be used to protect the tissue surrounding the treatment area. Radiation treatments are painless and usually last a few minutes.
    • internal radiation (brachytherapy, implant radiation) - radiation is given inside the body as close to the cancer as possible. A capsule containing radioisotopes, substances that produce radiation, is placed in the cervix. It is usually left in place for a few days. This type of internal radiation therapy may also be called low-dose rate (LDR) brachytherapy. Internal radiation involves giving a higher dose of radiation in a shorter time span than with external radiation. Hospitalization is required when an internal radiation implant is in place. In some cases, both internal and external radiation therapies are used. A newer type of internal radiation therapy, called high-dose rate (HDR) brachytherapy, or alternative implant therapy, uses a higher dose of internal radiation over a shorter period of time. This procedure can be completed in a few hours, and does not necessarily require a hospital stay.
  • chemotherapy - the use of anticancer drugs to treat cancerous cells. In most cases, chemotherapy works by interfering with the cancer cell’s ability to grow or reproduce. Different groups of drugs work in different ways to fight cancer cells. The oncologist will recommend a treatment plan for each individual.
  • biological therapy (also called biological response modifier, or BRM, therapy or immunotherapy) - biological therapy fights cancer by using materials made by your own body, or made in a laboratory, to boost, direct, or restore your body's natural defenses against disease.

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