Professor Emeritus, Department of Psychiatry and Behavioral Sciences
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EDUCATION | University of Kansas, Lawrence, KS | B.A. | 1961 | Psychology | | University of Kansas, Lawrence, KS | M.S. | 1966 | Psychology | | University of Tennessee, Knoxville, TN | Ph.D. | 1970 | Psychology/Physiology |
PROFESSIONAL EXPERIENCE | 1970-1972 | Associate, Department of Biochemistry and Department of Psychiatry & Behavioral Sciences, MUSC, Charleston, SC | | 1972-1977 | Assistant Professor, Department of Biochemistry and Department of Psychiatry & Behavioral Sciences, MUSC, Charleston, SC | | 1977-1982 | Associate Professor, Department of Biochemistry, MUSC, Charleston, SC
| | 1981-1982 | Visiting Researcher, National Institute of Aging, Gerontology Research Center, Baltimore, Maryland | | 1988-2005 | Professor, Department of Psychiatry & Behavioral Sciences, MUSC, Charleston, SC | | 2000-2005 | Professor, Department of Neurosciences, MUSC, Charleston, SC | | 2005-present | Professor Emeritus, Department of Psychiatry & Behavioral Sciences, MUSC, Charleston, SC |
AWARDS AND HONORS
| 1979-present | NIAAA, NIEHA, NINDS Ad hoc | | 1981-1982 | Fellow, National Institute on Aging | | 1982-1988 | Editorial Advisory Board, Neurotoxicology and Teratology | | 1984-present | Member, Research Society on Alcoholism | | 1988-1992 | Member, Biomedical Research Review Committee Member, NIDA | | 1989-1992 | Editorial Advisory Board: Pharmacology Biochemistry and Behavior | | 1990-1997 | Editorial Advisory Board: Neurotoxicology Teratology | | 1997 | NIDA Center Grant Member | | 1999 | NIDA Center Grant Member | | 1999-2003 | Editorial Advisory Board: Neurotoxicology Teratology | | 2000 | NIDA Special Interest Panel Chair | | 2002 | NIAAA Medications Development Workshop | | 2005-2006 | NIDA-K |
PUBLICATIONS (2006-present)
Boger HA, Middaugh LD, Huang P, Zaman V, Smith AC, Hoffer BJ, Tomac AC & Granholm AC. A partial GDNF depletion leads to earlier age-related deterioration of motor function and tyrosine hydroxylase expression in the substantia nigra. Experimental Neurology 202(2):336-347, 2006. Griffin WC, 3rd, Boger HA, Granholm AC & Middaugh LD. Partial deletion of glial cell line-derived neurotrophic factor (GDNF) in mice: Effects on sucrose reward and striatal GDNF concentrations. Brain Research 1068(1):257-260, 2006. Griffin WC, 3rd & Middaugh LD. The influence of sex on extracellular dopamine and locomotor activity in C57BL/6J mice before and after acute cocaine challenge. Synapse 59(2):74-81, 2006. Lominac KD, Kapasova Z, Hannun RA, Patterson C, Middaugh LD & Szumlinski KK. Behavioral and neurochemical interactions between Group 1 mGluR antagonists and ethanol: Potential insight into their anti-addictive properties. Drug and Alcohol Dependence 85(2):142-156, 2006. Melendez RI, Middaugh LD & Kalivas PW. Development of an alcohol deprivation and escalation effect in C57BL/6J mice. Alcoholism: Clinical & Experimental Research 30(12):2017-2025, 2006. Wiren KM, Hashimoto JG, Alele PE, Devaud LL, Price KL, Middaugh LD, Grant KA & Finn DA. Impact of sex: Determination of alcohol neuroadaptation and reinforcement. Alcoholism: Clinical and Experimental Research 30(2):233-242, 2006. Zhu HJ, Wang JS, Devane CL, Williard RL, Donovan JL, Middaugh LD, Gibson BB, Patrick KS & Markowitz JS. The role of the polymorphic efflux transporter p-glycoprotein on the brain accumulation of d-methylphenidate and d-amphetamine. Drug Metabolism & Disposition 34(7):1116-1121, 2006. Boger HA, Middaugh LD, Patrick KS, Ramamoorthy S, Denehy ED, Zhu H, Pacchioni AM, Granholm A-C & McGinty JF. Long-term consequences of methamphetamine exposure in young adults are exacerbated in glial cell line-derived neurotrophic factor heterozygous mice. Journal of Neuroscience 27(33):8816-8825, 2007. Cook-Easterwood J, Middaugh LD, Griffin WC, 3rd, Khan I & Tyor WR. Highly active antiretroviral therapy of cognitive dysfunction and neuronal abnormalities in SCID mice with HIV encephalitis. Experimental Neurology 205(2):506-512, 2007. Griffin WC, 3rd, Middaugh LD & Becker HC. Voluntary ethanol drinking in mice and ethanol concentrations in the nucleus accumbens. Brain Research 1138:208-213, 2007. Griffin WC, 3rd, Middaugh LD & Tyor WR. Chronic cocaine exposure in the SCID mouse model of HIV encephalitis. Brain Research 1134(1):214-219, 2007. Griffin WC, 3rd, Randall PK & Middaugh LD. Intravenous cocaine self-administration: Individual differences in male and female C57BL/6J mice. Pharmacology, Biochemistry & Behavior 87(2):267-279, 2007. Nguyen SA, Malcolm R & Middaugh LD. Topiramate reduces ethanol consumption by C57BL/6 mice. Synapse 61(3):150-156, 2007. Williard RL, Middaugh LD, Zhu H-JB & Patrick KS. Methylphenidate and its ethanol transesterification metabolite ethylphenidate: Brain disposition, monoamine transporters and motor activity. Behavioural Pharmacology 18(1):39-51, 2007. |
